Based on the provided URL, the GlyR1 Polyclonal Antibody (CAB9046) is a powerful tool for research involving GlyR1, a receptor protein that plays a significant role in the function of the inhibitory neurotransmitter glycine in the central nervous system. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.GlyR1 is essential for mediating inhibitory neurotransmission in the spinal cord and brainstem, making it a crucial target for studies related to neurological disorders, such as epilepsy, chronic pain, and movement disorders. By detecting and analyzing the expression of GlyR1 in different cell types, researchers can gain valuable insights into the mechanisms underlying these conditions.
Furthermore, the ability to accurately assess GlyR1 levels using this antibody opens up opportunities for the development of novel therapeutic strategies aimed at modulating glycine-mediated transmission in the treatment of neurological diseases. Overall, the GlyR1 Polyclonal Antibody (CAB9046) offers researchers a reliable tool for investigating the role of GlyR1 in various physiological and pathological processes, advancing our understanding of neurobiology and potential drug targets.
Product Name:
GLYR1 Rabbit Polyclonal Antibody
SKU:
CAB9046
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-270 of human GLYR1 (NP_115958.2).
Enables DNA binding activity; methylated histone binding activity; and nucleosome binding activity. Involved in positive regulation of histone acetylation and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of nucleosome.
Purification Method:
Affinity purification
Gene ID:
84656
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GLYR1 antibody (CAB9046) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
