The Glypican-3 Rabbit Monoclonal Antibody is a highly specific tool for researchers studying Glypican-3, a cell surface proteoglycan involved in various cellular processes, including cell growth and differentiation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to Glypican-3, researchers can effectively detect and analyze this protein in a wide range of cell types, making it an ideal choice for studies in cancer biology, developmental biology, and regenerative medicine.Glypican-3 is known for its role in cell proliferation and growth, and aberrant expression of this protein has been implicated in various types of cancer, making it a potential therapeutic target for cancer treatment.
By understanding the function and regulation of Glypican-3, researchers can gain insights into the molecular mechanisms underlying cancer progression and potentially develop new strategies for cancer therapy.Overall, the Glypican-3 Rabbit Monoclonal Antibody is a valuable tool for investigating the role of Glypican-3 in cellular processes and disease pathology, offering researchers the opportunity to advance our understanding of cancer biology and potentially identify new targets for therapeutic intervention.
Product Name:
Glypican 3 (GPC3) Rabbit Monoclonal Antibody
SKU:
CAB11686
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-211 of human Glypican 3 (GPC3) (P51654).
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2719
Clone Number:
ARC0675
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using Glypican 3 (GPC3) (GPC3) Rabbit mAb (CAB11686) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
