The Glypican-3 (GPC3) Monoclonal Antibody (CAB22608) is a cutting-edge tool for researchers studying GPC3, a cell surface protein involved in cell growth, development, and cancer progression. This monoclonal antibody, generated in mice, demonstrates high specificity and sensitivity in detecting GPC3 in human samples, making it a reliable choice for immunohistochemistry and flow cytometry applications.GPC3 is a promising target for cancer therapy due to its overexpression in various types of cancer, including hepatocellular carcinoma and melanoma.
By using the GPC3 Monoclonal Antibody, researchers can investigate the role of GPC3 in cancer development and explore its potential as a diagnostic marker or therapeutic target. This antibody's ability to specifically recognize GPC3 in different cell types makes it a versatile tool for advancing cancer research and drug discovery efforts.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2719
Clone Number:
ARC56906
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Glypican 3 (GPC3) antibody (CAB22608) at 1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
