The Glutathione Peroxidase 2 Monoclonal Antibody is a valuable tool for researchers studying the role of glutathione peroxidase 2 (GPX2) in oxidative stress and cell protection. This antibody, produced using hybridoma technology, specifically recognizes GPX2 in human samples and is suitable for use in a variety of applications, including Western blot and immunohistochemistry.GPX2 is a key antioxidant enzyme that plays a crucial role in protecting cells from damage caused by reactive oxygen species. Dysregulation of GPX2 has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.
By targeting GPX2 with this monoclonal antibody, researchers can better understand its function and potential therapeutic implications in these disease processes.Overall, the Glutathione Peroxidase 2 Monoclonal Antibody is a valuable tool for investigating the biological functions of GPX2 and its implications in disease pathogenesis. Its high specificity and reliability make it an essential reagent for studies in molecular biology, biochemistry, and biomedical research.
Product Name:
Glutathione Peroxidase 2 Monoclonal Antibody
SKU:
CAB11171
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-174 of human Glutathione Peroxidase 2 (NP_002074.2).
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2877
Clone Number:
ARC1801
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Glutathione Peroxidase 2 Rabbit mAb (CAB11171) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
