The Glutaredoxin-1 Polyclonal Antibody (CAB5315) is a powerful tool for researchers studying Glutaredoxin-1, a key antioxidant enzyme involved in redox signaling and cell protection. This antibody, raised in rabbits, is highly specific for human samples and has been extensively validated for Western blot applications. By binding to Glutaredoxin-1, this antibody enables accurate detection and analysis of the enzyme in a variety of cell types, making it an essential tool for studies in oxidative stress, cell signaling, and cancer research.
Glutaredoxin-1 is a critical player in maintaining cellular redox balance and protecting cells from oxidative damage. Its role in regulating redox signaling pathways and enzyme activities makes it a valuable target for investigation in the fields of cell biology, cancer research, and neurodegenerative diseases. Understanding the functions of Glutaredoxin-1 can provide insight into disease mechanisms and potentially lead to the development of novel therapies targeting oxidative stress-related conditions.
Product Name:
GLRX Rabbit Polyclonal Antibody
SKU:
CAB5315
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human GLRX (NP_002055.1).
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
Purification Method:
Affinity purification
Gene ID:
2745
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GLRX Rabbit pAb (CAB5315) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
