The Glutamine Synthetase (GLUL) Polyclonal Antibody is a valuable tool for researchers studying the role of GLUL in various biological processes. GLUL is an enzyme that plays a crucial role in the production of the amino acid glutamine, which is essential for protein synthesis and nitrogen metabolism in cells.This polyclonal antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. It binds to the GLUL protein, allowing for detection and analysis in a variety of cell types. This antibody is ideal for studies in metabolism, cellular signaling, and cancer research, where GLUL dysregulation has been implicated in tumor growth and progression.
Understanding the function of GLUL is important for unraveling its role in various physiological and pathological processes. By utilizing the GLUL Polyclonal Antibody, researchers can further investigate the intricate mechanisms involving glutamine metabolism and its impact on cellular function, paving the way for potential therapeutic interventions in diseases such as cancer and metabolic disorders.
Product Name:
Glutamine Synthetase (GLUL) Polyclonal Antibody
SKU:
CAB21822
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-373 of human Glutamine Synthetase (GLUL) (NP_002056.2).
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2752
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Glutamine Synthetase (GLUL) Rabbit pAb (CAB21822) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
