The GluR1 Rabbit Monoclonal Antibody is a cutting-edge tool for researchers studying the GluR1 protein, a crucial component of the AMPA receptor involved in synaptic plasticity and neuronal signaling. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity in detecting GluR1 in various samples, making it a valuable asset for neuroscience research.GluR1, a key player in excitatory neurotransmission, is essential for processes such as learning and memory. Dysregulation of GluR1 function has been implicated in neurological disorders including Alzheimer's disease, epilepsy, and depression.
By targeting GluR1 with this antibody, researchers can investigate the role of this protein in disease pathology and potential therapeutic interventions.With its ability to reliably detect and analyze GluR1 expression in experimental settings such as immunohistochemistry and flow cytometry, the GluR1 Rabbit Monoclonal Antibody offers a versatile and powerful tool for advancing our understanding of synaptic function and neurological disorders.
Product Name:
GluR1/GRIA1 Rabbit Monoclonal Antibody
SKU:
CAB11643
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 800-906 of human GluR1/GRIA1 (P42261).
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2890
Clone Number:
ARC0657
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GluR1/GRIA1 Rabbit mAb (CAB11643) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
