GLUD1 Rabbit Polyclonal Antibody (CAB7631)
- SKU:
- CAB7631
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | GLUD1 Rabbit Polyclonal Antibody |
SKU: | CAB7631 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 54-242 of human GLUD1 (NP_005262.1). |
Sequence: | SEAV ADRE DDPN FFKM VEGF FDRG ASIV EDKL VEDL RTRE SEEQ KRNR VRGI LRII KPCN HVLS LSFP IRRD DGSW EVIE GYRA QHSQ HRTP CKGG IRYS TDVS VDEV KALA SLMT YKCA VVDV PFGG AKAG VKIN PKNY TDNE LEKI TRRF TMEL AKKG FIGP GIDV PAPD MSTG EREM SWIA DTYA S |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | GDH; GDH1; GLUD; hGDH1; GLUD1 |
Positive Sample: | HeLa,HepG2,NIH/3T3,U-251MG,Mouse liver,Mouse brain,Rat liver,Rat brain,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 61kDa |
Observed MW: | 52kDa |
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
Purification Method: | Affinity purification |
Gene ID: | 2746 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |