The GluD1 Polyclonal Antibody (CAB7631) is a valuable tool for researchers studying the GluD1 protein, a component of the glutamate receptor family that plays a crucial role in synaptic transmission and plasticity. This antibody, produced in rabbits, has high specificity and sensitivity for detecting GluD1 in human samples, making it suitable for use in techniques such as Western blotting.The GluD1 protein is involved in excitatory neurotransmission in the brain, making it a key player in processes like learning and memory. Dysregulation of GluD1 has been linked to neurological disorders such as epilepsy and schizophrenia, making it an important target for research in neuroscience and drug development.
By using the GluD1 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of the GluD1 protein in the central nervous system. This antibody is a reliable tool for studying the role of GluD1 in both normal brain function and disease states, paving the way for new therapeutic strategies and interventions in neurological disorders.
Product Name:
GLUD1 Rabbit Polyclonal Antibody
SKU:
CAB7631
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 54-242 of human GLUD1 (NP_005262.1).
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
Purification Method:
Affinity purification
Gene ID:
2746
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GLUD1 Rabbit pAb (CAB7631) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
