GLUD1 Rabbit Monoclonal Antibody (CAB5176)
- SKU:
- CAB5176
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | GLUD1 Rabbit Monoclonal Antibody |
SKU: | CAB5176 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 459-558 of human GLUD1 (P00367). |
Sequence: | ERDS NYHL LMSV QESL ERKF GKHG GTIP IVPT AEFQ DRIS GASE KDIV HSGL AYTM ERSA RQIM RTAM KYNL GLDL RTAA YVNA IEKV FKVY NEAG VTFT |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | GDH; GDH1; GLUD; hGDH1; GLUD1 |
Positive Sample: | Jurkat,K-562,U-251MG,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum, Mitochondrion. |
Calculated MW: | 61kDa |
Observed MW: | 52kDa |
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
Purification Method: | Affinity purification |
Gene ID: | 2746 |
Clone Number: | ARC1216 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |