Glucokinase (GCK) Rabbit Monoclonal Antibody (CAB5170)
- SKU:
- CAB5170
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | Glucokinase (GCK) Rabbit Monoclonal Antibody |
SKU: | CAB5170 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 271-421 of human Glucokinase (GCK) (P35557). |
Sequence: | LEYD RLVD ESSA NPGQ QLYE KLIG GKYM GELV RLVL LRLV DENL LFHG EASE QLRT RGAF ETRF VSQV ESDT GDRK QIYN ILST LGLR PSTT DCDI VRRA CESV STRA AHMC SAGL AGVI NRMR ESRS EDVM RITV GVDG SVYK LHPS FKE |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; PNDM1; FGQTL3; Glucokinase (GCK) |
Positive Sample: | HeLa,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus |
Calculated MW: | 52kDa |
Observed MW: | 52kDa |
This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia.
Purification Method: | Affinity purification |
Gene ID: | 2645 |
Clone Number: | ARC1226 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |