Glucokinase (GCK) Rabbit Polyclonal Antibody (CAB6293)
- SKU:
- CAB6293
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | Glucokinase (GCK) Rabbit Polyclonal Antibody |
SKU: | CAB6293 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human Glucokinase (GCK) (NP_000153.1). |
Sequence: | MLDD RARM EAAK KEKV EQIL AEFQ LQEE DLKK VMRR MQKE MDRG LRLE THEE ASVK MLPT YVRS TPEG SEVG DFLS LDLG GTNF RVML VKVG EGEE GQWS VKTK HQMY SIPE DAMT GTAE MLFD YISE CISD FLDK HQMK HKKL PLGF TFSF PVRH EDID KGIL LNWT KGFK ASGA EGNN VVGL LRDA IKRR GDFE MDVV AMVN DTVA TMIS CYYE DHQC EVGM IVGT GCNA CYME EMQN VELV EGDE GRMC VNTE WGAF GDSG ELDE FLLE YDRL VDES SANP GQQL YEKL IGGK YMGE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; PNDM1; FGQTL3; Glucokinase (GCK) |
Positive Sample: | Mouse liver,Rat skeletal muscle |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 52kDa |
Observed MW: | 52kDa |
This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia.
Purification Method: | Affinity purification |
Gene ID: | 2645 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |