The Glucocorticoid Receptor Rabbit Monoclonal Antibody (CAB19583) is a high-quality antibody designed for research involving the glucocorticoid receptor, a key regulator of various physiological processes including metabolism, immune response, and stress. This antibody, generated from rabbits, exhibits strong reactivity with human samples and is validated for use in techniques such as Western blotting and immunohistochemistry.The glucocorticoid receptor is a nuclear receptor that plays a crucial role in mediating the effects of glucocorticoid hormones, which are involved in immune response regulation, inflammation, and stress adaptation. Dysregulation of this receptor has been implicated in various diseases such as inflammatory disorders, autoimmune conditions, and certain types of cancer.
By specifically targeting the glucocorticoid receptor, researchers can gain valuable insights into its role in disease pathology and potential therapeutic interventions. This monoclonal antibody allows for precise detection and analysis of the receptor in different cell types, making it an indispensable tool for studies in immunology, endocrinology, and cancer research. Unlocking the molecular mechanisms underlying glucocorticoid receptor function holds promise for the development of novel treatments and therapies for a wide range of health conditions.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Purification Method:
Affinity purification
Gene ID:
2908
Clone Number:
ARC0062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Glucocorticoid Receptor Rabbit mAb (CAB19583) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
