Glucocorticoid Receptor Rabbit Monoclonal Antibody (CAB19583)
- SKU:
- CAB19583
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | Glucocorticoid Receptor Rabbit Monoclonal Antibody |
SKU: | CAB19583 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2-180 of human GR (P04150). |
Sequence: | DSKE SLTP GREE NPSS VLAQ ERGD VMDF YKTL RGGA TVKV SASS PSLA VASQ SDSK QRRL LVDF PKGS VSNA QQPD LSKA VSLS MGLY MGET ETKV MGND LGFP QQGQ ISLS SGET DLKL LEES IANL NRST SVPE NPKS SAST AVSA APTE KEFP KTHS DVSS EQQH LKGQ TGTN GGN |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | GR; GCR; GRL; GCCR; GCRST; Glucocorticoid Receptor |
Positive Sample: | U-251MG,OVCAR3,HepG2,HeLa,Mouse liver,Mouse kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion, Nucleus. |
Calculated MW: | 86kDa |
Observed MW: | 95kDa |
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Purification Method: | Affinity purification |
Gene ID: | 2908 |
Clone Number: | ARC0062 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |