The GLUA4 Rabbit Monoclonal Antibody (CAB4593) is a cutting-edge tool designed for researchers studying the GLUA4 protein, a key player in neurobiology and synaptic plasticity. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an excellent choice for Western blot applications. By binding to the GLUA4 protein, this antibody enables precise detection and analysis in various cell types, offering valuable insights into the mechanisms underlying neurological disorders and cognitive functions.GLUA4, a subunit of the AMPA receptor family, is essential for mediating fast synaptic transmission in the brain and regulating synaptic strength. Dysregulation of GLUA4 has been linked to various neurological conditions, including epilepsy, Alzheimer's disease, and mood disorders.
Understanding the role of GLUA4 in synaptic activity and plasticity is crucial for developing targeted therapies for these disorders and advancing our knowledge of brain function.By utilizing the GLUA4 Rabbit Monoclonal Antibody (CAB4593), researchers can uncover new insights into the function of GLUA4 and its implications for neurological health. This antibody is a valuable tool for studies in neuroscience, pharmacology, and neurodegenerative diseases, offering a deeper understanding of synaptic transmission and potential therapeutic targets.
Product Name:
GluR4/GluA4/GRIA4 Rabbit Monoclonal Antibody
SKU:
CAB4593
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 800-902 of human GluR4/GluA4/GRIA4 (P48058).
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.
Purification Method:
Affinity purification
Gene ID:
2893
Clone Number:
ARC1045
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GluR4/GluA4/GRIA4Rabbit mAb (CAB4593) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
