The GLRA3 Antibody (PACO09486) is a highly specific and sensitive tool for researchers studying the glycine receptor alpha 3 subunit, a key player in inhibitory neurotransmission in the central nervous system. This polyclonal antibody, produced in rabbits, has been rigorously validated for use in immunohistochemistry and immunofluorescence experiments with human samples.The glycine receptor alpha 3 subunit is essential for mediating fast inhibitory neurotransmission in the spinal cord and brain stem, and dysregulation of this receptor has been implicated in neurological disorders such as epilepsy and schizophrenia. By targeting the GLRA3 protein, researchers can gain insights into the role of this receptor in synaptic transmission and its potential as a therapeutic target for neurological diseases.
With its high specificity and sensitivity, the GLRA3 Antibody (PACO09486) is an invaluable tool for investigating the function and regulation of the glycine receptor alpha 3 subunit in both normal and pathological neurological conditions. Researchers can use this antibody to study the expression and localization of GLRA3 in various cell types and tissues, advancing our understanding of the molecular mechanisms underlying neurological disorders.
GLRA3: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Transporter; Transporter, ion channel; Membrane protein, integralChromosomal Location of Human Ortholog: 4q34.1Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junctionMolecular Function: transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine bindingBiological Process: transmembrane transport
UniProt Protein Details:
NCBI Summary:
The GLRA3 gene encodes the alpha-3 subunit of the neuronal glycine receptor, a ligand-gated chloride channel composed of ligand-binding alpha and structural beta polypeptides (Kingsmore et al., 1994 [PubMed 7894176]).[supplied by OMIM]
