The GLP1R Polyclonal Antibody (CAB8547) is a valuable tool for researchers studying GLP1R, a cell surface receptor involved in glucose homeostasis and insulin secretion. This antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for use in Western blot applications. By binding specifically to the GLP1R protein, researchers can detect and analyze its expression in various cell types, making it ideal for investigations in diabetes research and metabolic disorders.
GLP1R, also known as the glucagon-like peptide 1 receptor, plays a crucial role in regulating blood sugar levels and insulin release in response to food intake. Dysregulation of GLP1R signaling is associated with conditions like type 2 diabetes, making it a promising target for therapeutic interventions aimed at improving glucose control and metabolic health. Research into the function of GLP1R is essential for developing novel treatments for diabetes and related metabolic disorders.
Product Name:
GLP1R Rabbit Polyclonal Antibody
SKU:
CAB8547
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human GLP1R (NP_002053.3).
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2740
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GLP1R antibody (CAB8547) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
