The GLP1R Polyclonal Antibody (CAB13990) is a valuable tool for researchers studying the GLP1R protein, a key receptor involved in glucose homeostasis and insulin secretion. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it suitable for use in Western blot applications. By specifically binding to the GLP1R protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating research in the fields of diabetes, obesity, and metabolic disorders.The GLP1R receptor plays a crucial role in regulating blood sugar levels and insulin release in response to food intake.
Dysregulation of GLP1R signaling is associated with conditions such as type 2 diabetes and obesity, making it an attractive target for therapeutic interventions. By studying the function and expression of the GLP1R protein, researchers can gain insights into potential treatment strategies for metabolic disorders and related complications. Overall, the GLP1R Polyclonal Antibody (CAB13990) provides a valuable tool for investigating the role of the GLP1R protein in health and disease, offering researchers a reliable means to explore new avenues in the development of treatments for metabolic disorders.
Product Name:
GLP1R Rabbit Polyclonal Antibody
SKU:
CAB13990
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-116 of human GLP1R (NP_002053.3).
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2740
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of U-87MG cells, using GLP1R antibody (CAB13990) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
