GLE1 Rabbit Polyclonal Antibody (CAB13206)
- SKU:
- CAB13206
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | GLE1 Rabbit Polyclonal Antibody |
SKU: | CAB13206 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GLE1 (NP_001003722.1). |
Sequence: | MPSE GRCW ETLK ALRS SDKG RLCY YRDW LLRR EDVL EECM SLPK LSSY SGWV VEHV LPHM QENQ PLSE TSPS STSA SALD QPSF VPKS PDAS SAFS PASP ATPN GTKG KDES QHTE SMVL QSSR GIKV EGCV RMYE LVHR MKGT EGLR LWQE EQER KVQA LSEM ASEQ LKRF DEWK ELKQ HKEF QDLR EVME KSSR EALG HQEK LKAE HRHR AKIL NLKL REAE QQRV KQAE QERL RKEE GQIR LRAL YALQ EEML QLSQ QLDA SEQH KALL KVDL AAFQ TRGN QLCS LISG IIRA SSES |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | LCCS; CAAHC; CAAHD; GLE1L; LCCS1; hGLE1; GLE1 |
Positive Sample: | Mouse spleen,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasm, Nucleus, nuclear pore complex. |
Calculated MW: | 80kDa |
Observed MW: | 80kDa |
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2733 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |