The GLCCI1 Polyclonal Antibody (CAB15934) is a valuable tool for researchers studying the GLCCI1 gene, which has been associated with glucocorticoid response and asthma susceptibility. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the GLCCI1 protein, this antibody enables the detection and analysis of GLCCI1 expression in various cell types. Its high reactivity and specificity make it an ideal choice for research in the fields of immunology and respiratory diseases.
GLCCI1 is a key genetic regulator of glucocorticoid response, playing a crucial role in the anti-inflammatory effects of glucocorticoids in the body. Dysregulation of GLCCI1 has been linked to increased asthma susceptibility and poor response to glucocorticoid treatment. By studying the function and regulation of GLCCI1, researchers can gain valuable insights into the mechanisms underlying asthma and potentially identify new therapeutic targets for this common respiratory condition.
Antibody Name:
Anti-GLCCI1 Antibody
Antibody SKU:
CAB15934
Antibody Size:
20uL, 50uL, 100uL
Application:
WB
Reactivity:
Human, Mouse
Host Species:
Rabbit
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-230 of human GLCCI1 (NP_612435.1).
Application:
WB
Recommended Dilution:
WB 1:500 - 1:2000
Reactivity:
Human, Mouse
Positive Samples:
HepG2, Mouse thymus, Mouse brain, Mouse heart
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-230 of human GLCCI1 (NP_612435.1).
Purification Method:
Affinity purification
Storage Buffer:
Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients.
UniProt Protein Function:
GLCCI1:
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 7p21.3
Disease: Glucocorticoid Therapy, Response To
NCBI Summary:
This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]
Western blot analysis of extracts of various cell lines, using GLCCI1 antibody (CAB15934) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
