The GLB1 Polyclonal Antibody (CAB13668) is a valuable tool for researchers studying GLB1, a lysosomal enzyme involved in lysosomal storage disorders such as GM1 gangliosidosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blot and immunohistochemistry.GLB1 plays a critical role in breaking down complex sugars within cells, and mutations in the GLB1 gene can result in the accumulation of these sugars, leading to severe neurological and systemic symptoms.
By targeting GLB1 with this polyclonal antibody, researchers can investigate the expression and localization of the enzyme in different cell types and tissues, aiding in the understanding of lysosomal storage disorders and potential therapeutic strategies.
Product Name:
GLB1 Rabbit Polyclonal Antibody
SKU:
CAB13668
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human GLB1 (NP_000395.3).
This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates. Mutations in this gene may result in GM1-gangliosidosis and Morquio B syndrome.
Purification Method:
Affinity purification
Gene ID:
2720
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GLB1 antibody (CAB13668) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
