The GLA Polyclonal Antibody (CAB1700) is a valuable tool for researchers studying the GLA protein, a key enzyme involved in the breakdown of fatty acids. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GLA protein, researchers can accurately detect and analyze its expression in a variety of cell types.GLA, also known as alpha-galactosidase A, is essential for the breakdown of a specific type of lipid molecule called globotriaosylceramide. Deficiencies in GLA enzyme activity have been linked to Fabry disease, a rare genetic disorder characterized by the buildup of these lipid molecules in various tissues throughout the body.
Research into GLA function is crucial for understanding the underlying mechanisms of Fabry disease and developing potential treatments for this debilitating condition.By utilizing the GLA Polyclonal Antibody (CAB1700), researchers can further explore the role of the GLA enzyme in lipid metabolism, cellular function, and disease pathology. This antibody is a valuable asset for studies in molecular biology, biochemistry, and medical research, offering insight into the intricate workings of the human body at the molecular level.
Recombinant fusion protein containing a sequence corresponding to amino acids 150-429 of human Galactosidase alpha (Galactosidase alpha (GLA)) (NP_000160.1).
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.
Purification Method:
Affinity purification
Gene ID:
2717
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Galactosidase alpha (Galactosidase alpha (GLA)) antibody (CAB1700) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
