The GK Polyclonal Antibody (CAB6377) is a versatile tool for researchers studying GK, a key enzyme involved in glucose metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications such as Western blotting. By binding specifically to the GK protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component in studies related to diabetes, metabolic disorders, and other conditions affecting glucose regulation.GK, also known as glucokinase, plays a crucial role in glucose homeostasis by catalyzing the conversion of glucose to glucose-6-phosphate in the liver and pancreatic beta cells.
Dysregulation of GK activity is associated with diabetes and other metabolic disorders, making it a promising target for therapeutic interventions. Research into the function and regulation of GK is essential for developing new treatments and improving our understanding of glucose metabolism-related diseases. Overall, the GK Polyclonal Antibody (CAB6377) offers researchers a valuable tool for studying the role of GK in health and disease, with the potential to advance our knowledge and contribute to the development of novel therapies in the field of metabolic research.
Product Name:
Glycerol kinase (GK) Rabbit Polyclonal Antibody
SKU:
CAB6377
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 422-559 of Glycerol kinase (GK) (NP_001191948.1).
The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2710
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Glycerol kinase (GK) Rabbit pAb (CAB6377) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
