The GJC3 Polyclonal Antibody (PAC017742) is a valuable tool for researchers studying GJC3, a protein involved in cell-cell communication and crucial for various physiological processes. This antibody, produced in rabbits, exhibits high reactivity with samples from multiple species and is validated for use in immunofluorescence and immunohistochemistry applications.GJC3, also known as gap junction gamma-3 protein, is a component of gap junctions that facilitate the direct exchange of ions and small molecules between adjacent cells. Dysregulation of these communication channels has been linked to various diseases, including cancer, neurological disorders, and cardiovascular conditions.
By targeting GJC3, researchers can gain insight into the role of gap junctions in health and disease, potentially leading to the development of novel therapeutics targeting cell communication pathways.Overall, the GJC3 Polyclonal Antibody presents a valuable tool for investigating the function and regulation of GJC3 in different biological contexts, offering new possibilities for understanding and targeting intercellular communication mechanisms.
Antibody Name:
Gjc3 Antibody (PACO17742)
Antibody SKU:
PACO17742
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of mouse Gjc3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17742(Gjc3 Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17742(Gjc3 Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Gap junction gamma-3, also known as connexin-30.2 (Cx30.2) or connexin-31.3 (Cx31.3) or gap junction epsilon-1 (GJE1), is a protein that in humans is encoded by the GJC3 gene. GJC3 is a connexin. This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.
Synonyms:
gap junction protein, γ 3
UniProt Protein Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
