The GJC2 Polyclonal Antibody (CAB2885) is a valuable tool for researchers studying the GJC2 protein, a critical component of gap junctions that play a key role in cell communication. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blotting.GJC2, also known as connexin 47, is an important protein involved in the formation and function of gap junction channels, which allow for the direct exchange of ions and small molecules between adjacent cells. Dysfunction of GJC2 has been linked to various diseases, including Pelizaeus-Merzbacher-like disease and lymphedema.
Studying the expression and function of GJC2 using this antibody can provide valuable insights into the mechanisms underlying these disorders.This GJC2 Polyclonal Antibody is an essential tool for researchers investigating the role of GJC2 in cellular communication and its implications for human health. Its specificity and sensitivity make it an ideal choice for studies in neurobiology, developmental biology, and disease pathology. By enabling the detection and analysis of GJC2 protein in different cell types, this antibody contributes to a deeper understanding of gap junction function and its relevance to various physiological processes.
Product Name:
GJC2 Rabbit Polyclonal Antibody
SKU:
CAB2885
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human GJC2 (Q5T442).
Cell junction, Cell membrane, Multi-pass membrane protein, gap junction.
Calculated MW:
47kDa
Observed MW:
47kDa
This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.
Purification Method:
Affinity purification
Gene ID:
57165
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using GJC2 Rabbit pAb (CAB2885) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
