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GJB7 Antibody (PACO22344)

SKU:
PACO22344
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$503

Description

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GJB7 Antibody (PACO22344)

The GJB7 Antibody (PAC022344) is a highly specific and sensitive tool for researchers studying the role of GJB7 in various physiological and pathological processes. GJB7, also known as Connexin25, is a gap junction protein involved in cell communication and homeostasis. This polyclonal antibody, produced in rabbits, is optimized for use in Western blot assays and has been validated for detection of GJB7 in human samples. Its high reactivity and specificity make it ideal for studies in cell biology, neurobiology, and developmental biology.

By targeting GJB7, researchers can explore its role in cell signaling, tissue development, and disease progression. This antibody provides a valuable tool for investigating the mechanisms underlying gap junction function and dysfunction, with potential implications for understanding and treating various disorders.

Antibody Name:GJB7 Antibody (PACO22344)
Antibody SKU:PACO22344
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human GJB7.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from HT-29 cells, using GJB7 antibody.
Background:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.
Synonyms:connexin25; CX25; CXB7; gap junction protein; beta 7
UniProt Protein Function:GJB7: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 6q15Cellular Component: connexon complex; integral to membraneBiological Process: cell communication
UniProt Protein Details:
NCBI Summary:Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
UniProt Code:Q6PEY0
NCBI GenInfo Identifier:74749171
NCBI Gene ID:375519
NCBI Accession:Q6PEY0.1
UniProt Secondary Accession:Q6PEY0,Q96KP0, B3KXL0
UniProt Related Accession:Q6PEY0
Molecular Weight:25,860 Da
NCBI Full Name:Gap junction beta-7 protein
NCBI Synonym Full Names:gap junction protein beta 7
NCBI Official Symbol:GJB7  
NCBI Official Synonym Symbols:CX25; bA136M9.1; connexin25  
NCBI Protein Information:gap junction beta-7 protein
UniProt Protein Name:Gap junction beta-7 protein
UniProt Synonym Protein Names:Connexin-25; Cx25
Protein Family:Gap junction beta-7 protein
UniProt Gene Name:GJB7  
UniProt Entry Name:CXB7_HUMAN
Antibodies
GJB7 Antibody (PACO00625)
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