The GJB7 Polyclonal Antibody (PACO00625) is specifically designed for research involving GJB7, a member of the connexin family of gap junction proteins that plays a crucial role in cell communication and signaling. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the GJB7 protein, researchers can detect and analyze its expression in various cell types, making it an ideal tool for studies in cell biology and molecular biology.GJB7, also known as connexin 25, is involved in the formation of gap junction channels that allow for the direct exchange of ions and small molecules between cells.
These channels play a vital role in cell signaling, growth control, and differentiation, making GJB7 a key player in various cellular processes. Research into GJB7 function is critical for understanding its role in development, homeostasis, and disease, particularly in conditions related to cell communication and signaling abnormalities.Overall, the GJB7 Polyclonal Antibody offers a valuable tool for researchers interested in studying the function and regulation of GJB7 in various biological contexts. Its high specificity and sensitivity make it a reliable choice for investigating the intricate mechanisms underlying cell communication and signaling pathways.
Antibody Name:
GJB7 Antibody
Antibody SKU:
PACO00625
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Connexin 25.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
GJB7; CX25; Gap junction beta-7 protein; Connexin-25; Cx25
UniProt Protein Function:
GJB7: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 6q15Cellular Component: connexon complex; integral to membraneBiological Process: cell communication
UniProt Protein Details:
NCBI Summary:
Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
