The GJB5 Polyclonal Antibody (PAC026993) is a valuable tool for researchers studying the expression and function of GJB5, a member of the gap junction beta family of proteins. This antibody, produced in rabbits, is highly selective for human samples and has been validated for use in Western blot applications. By specifically binding to GJB5 protein, this antibody enables the detection and analysis of GJB5 in various cell types, making it an essential tool for studies in cell biology and molecular biology.GJB5, also known as connexin-31.1, is a key component of gap junction channels that facilitate direct cell-to-cell communication. Its role in regulating the exchange of ions and small molecules between cells makes it essential for maintaining tissue homeostasis and proper physiological function.
Dysregulation of GJB5 has been implicated in various diseases, including skin disorders and hearing impairments, highlighting its importance for further research in these areas.By using the GJB5 Polyclonal Antibody, researchers can gain valuable insights into the expression levels and localization of GJB5 in different cell types and tissues. This antibody is a powerful tool for elucidating the function of GJB5 and its potential role in disease pathogenesis, paving the way for the development of novel therapeutic strategies targeting GJB5-related pathways.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO26993 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO26993 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Synonyms:
Gap junction beta-5 protein (Connexin-31.1) (Cx31.1), GJB5
UniProt Protein Function:
GJB5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily.Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1p35.1Biological Process: epidermis development
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]
