The GJB5 Polyclonal Antibody (PACO21019) is a valuable tool for researchers studying the GJB5 protein, also known as connexin 31.1. This antibody, produced in rabbits, shows high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the GJB5 protein, this antibody allows for the detection and analysis of GJB5 expression in various cell types.GJB5 is a member of the connexin family of proteins, which are involved in forming gap junctions that facilitate intercellular communication. Research has shown that GJB5 plays a role in various physiological processes, including skin development and hearing function.
Dysregulation of GJB5 has also been linked to skin diseases and hearing disorders.By studying the expression and function of GJB5, researchers can gain insights into its role in normal physiological processes and its potential involvement in disease. This antibody is a valuable tool for investigating the functions of GJB5 in skin biology, auditory systems, and other areas of research interest. Its use can contribute to a better understanding of the molecular mechanisms underlying various conditions, ultimately leading to the development of new therapies and interventions.
Antibody Name:
GJB5 Antibody (PACO21019)
Antibody SKU:
PACO21019
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human GJB5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO21019(GJB5 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer.
Synonyms:
gap junction protein, β 5, 31.1kDa
UniProt Protein Function:
GJB5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily.Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1p35.1Biological Process: epidermis development
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]
