The GJB3 Polyclonal Antibody (CAB2949) is a vital tool for researchers studying GJB3, a protein responsible for forming gap junction channels that allow for communication between cells. This antibody is raised in rabbits and is highly specific for detecting GJB3 in human samples, making it an ideal choice for use in Western blot applications. By binding to the GJB3 protein, researchers can effectively study its role in cell communication and its implications in various physiological processes.
GJB3, also known as Connexin 31, is essential for maintaining proper cell signaling and function in tissues throughout the body. Dysregulation of GJB3 has been implicated in various disorders, including skin diseases and hearing loss, making it a promising target for therapeutic interventions. By utilizing the GJB3 Polyclonal Antibody, researchers can further explore the mechanisms underlying these conditions and develop potential treatments to address them.
Product Name:
GJB3 Rabbit Polyclonal Antibody
SKU:
CAB2949
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GJB3 (NP_076872.1).
Cell junction, Cell membrane, Multi-pass membrane protein, gap junction.
Calculated MW:
31kDa
Observed MW:
31kDa
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
2707
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GJB3 antibody (CAB2949) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).
