GJA9 Antibody (PACO17740)
- SKU:
- PACO17740
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GJA9 Antibody (PACO17740)
The GJA9 Polyclonal Antibody (PAC017740) is a versatile tool for researchers studying GJA9, a gap junction protein involved in cell communication and signaling pathways. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.GJA9, also known as connexin 43, plays a crucial role in intercellular communication by forming gap junction channels that allow the passage of ions and small molecules between cells. Dysregulation of GJA9 has been linked to various diseases, including cancer, cardiovascular disorders, and neurological conditions.
Research into the function and regulation of GJA9 is essential for understanding its role in these diseases and potentially identifying new therapeutic targets.The GJA9 Polyclonal Antibody is a valuable tool for researchers investigating the function and regulation of GJA9 in different cell types and tissues. Its specificity and sensitivity make it an ideal choice for studies in cell biology, physiology, and disease mechanisms related to gap junction communication.
| Antibody Name: | GJA9 Antibody (PACO17740) |
| Antibody SKU: | PACO17740 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human GJA9 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal muscle tissue, Primary antibody: PACO17740(GJA9 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| Synonyms: | gap junction protein, α 9, 59kDa |
| UniProt Protein Function: | GJA9: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Alpha-type (group II) subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p34 Cellular Component: connexon complex; integral to membrane Biological Process: cell communication |
| NCBI Summary: | Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | P57773 |
| NCBI GenInfo Identifier: | 50403749 |
| NCBI Gene ID: | 81025 |
| NCBI Accession: | P57773.2 |
| UniProt Secondary Accession: | P57773,Q5TA63, Q96KG0, B2R722, B3KVQ2, |
| UniProt Related Accession: | P57773 |
| Molecular Weight: | 515 |
| NCBI Full Name: | Gap junction alpha-9 protein |
| NCBI Synonym Full Names: | gap junction protein, alpha 9, 59kDa |
| NCBI Official Symbol: | GJA9Â Â |
| NCBI Official Synonym Symbols: | CX58; CX59; GJA10Â Â |
| NCBI Protein Information: | gap junction alpha-9 protein; connexin 59; connexin-58; gap junction alpha 10 |
| UniProt Protein Name: | Gap junction alpha-9 protein |
| UniProt Synonym Protein Names: | Connexin-58; Cx58; Connexin-59; Cx59; Gap junction alpha-10 protein |
| Protein Family: | Gap junction alpha-9 protein |
| UniProt Gene Name: | GJA9Â Â |
| UniProt Entry Name: | CXA9_HUMAN |
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