The GJA3 Antibody (PACO09474) is a polyclonal antibody specifically designed for research involving GJA3, a crucial protein involved in cell communication and gap junction formation. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunofluorescence.Gap junction alpha-3 (GJA3) is a transmembrane protein that forms gap junction channels allowing the exchange of ions and small molecules between neighboring cells. These channels play a key role in cell signaling and coordination, making GJA3 a vital target for research in developmental biology, cell communication, and disease mechanisms.The GJA3 Antibody (PACO09474) binds specifically to GJA3 protein, enabling precise detection and analysis in various cell types and tissues.
Its application in immunofluorescence allows for visualization of gap junctions and cell-cell communication, providing valuable insights into cellular interactions and processes.Understanding the functions and regulation of GJA3 is crucial for unraveling the mechanisms underlying cell communication, tissue development, and disease progression. The GJA3 Antibody (PACO09474) serves as a powerful tool for researchers in the fields of cell biology, neuroscience, and cancer research, offering new possibilities for studying intercellular communication and gap junction dynamics.
GJA3: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA3 are the cause of cataract zonular pulverulent cataract type 3 (CZP3). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in GJA3 are a cause of cataract autosomal dominant (ADC). Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Belongs to the connexin family. Alpha-type (group II) subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 13q12.11Biological Process: cell-cell signaling; visual perceptionDisease: Cataract 14, Multiple Types
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]
