The GJA1 Polyclonal Antibody (CAB2163) is a specialized research tool designed for studying the role of GJA1, also known as connexin43, in cellular communication and signaling. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it an ideal choice for a variety of research applications, particularly in the fields of cell biology and neuroscience.GJA1 is a critical protein involved in gap junction communication between cells, facilitating the passage of ions and small molecules essential for intercellular signaling. Dysregulation of GJA1 has been implicated in various diseases, including cardiac disorders, neurological conditions, and certain cancers.
By using the GJA1 Polyclonal Antibody, researchers can detect and analyze GJA1 expression levels in different cell types, shedding light on its function and potential therapeutic implications.This antibody is validated for use in Western blot applications, providing researchers with a reliable tool for investigating the dynamics of GJA1 expression in various experimental conditions. By elucidating the role of GJA1 in cellular communication, this antibody contributes to our understanding of fundamental biological processes and may offer insights into the development of novel treatments for diseases associated with GJA1 dysfunction.
Product Name:
GJA1 Rabbit Polyclonal Antibody
SKU:
CAB2163
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 283-382 of human Connexin 43 (NP_000156.1).
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations.
Purification Method:
Affinity purification
Gene ID:
2697
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Connexin 43 Rabbit pAb (CAB2163) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
