The GJA1 Polyclonal Antibody (CAB11752) is a valuable tool for researchers studying connexin 43 (Cx43), a crucial protein involved in cell-to-cell communication. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the GJA1 protein, this antibody allows for the detection and analysis of Cx43 expression in a variety of cell types, making it an ideal choice for studies in cell biology, neuroscience, and cardiology.
Connexin 43 plays a vital role in various cellular processes, including cardiac conduction, neuronal signaling, and cell growth regulation. Dysregulation of Cx43 has been implicated in numerous diseases, such as arrhythmias, neurodegenerative disorders, and cancer. By understanding the function and regulation of Cx43, researchers can gain insights into the mechanisms underlying these conditions and potentially develop therapeutic strategies targeting Cx43 for treatment.
Product Name:
GJA1 Rabbit Polyclonal Antibody
SKU:
CAB11752
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 233-382 of human Connexin 43 (NP_000156.1).
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations.
Purification Method:
Affinity purification
Gene ID:
2697
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Connexin 43 Rabbit pAb (CAB11752) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
