The GIT2 Polyclonal Antibody (CAB15368) is a valuable tool for researchers studying GIT2, a GTP-binding protein involved in signaling pathways regulating cell migration and morphology. This antibody, generated in rabbits, exhibits high specificity for GIT2 in human samples and is suitable for use in Western blot applications. By binding to GIT2, this antibody enables the precise detection and analysis of GIT2 protein levels in various cell types, making it ideal for research in cell biology and signal transduction.GIT2, a member of the GIT (G-protein coupled receptor kinase-interacting protein) family, plays a crucial role in coordinating cellular processes such as cytoskeletal dynamics and cell adhesion. Its involvement in regulating cell migration and adhesion makes it a key player in processes like cell motility and tissue development.
By studying the function of GIT2, researchers can gain insights into its role in normal cellular functions as well as its potential implications in diseases such as cancer and neurological disorders.The GIT2 Polyclonal Antibody is a valuable tool for investigating the function of GIT2 in various biological contexts, providing researchers with the means to explore its role in cellular processes and disease pathology. By understanding the intricacies of GIT2 signaling, researchers can pave the way for the development of novel therapeutic strategies targeting GIT2-related pathways in different disease conditions.
Product Name:
GIT2 Rabbit Polyclonal Antibody
SKU:
CAB15368
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 450-510 of human GIT2 (NP_476511.1).
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Purification Method:
Affinity purification
Gene ID:
9815
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GIT2 Rabbit pAb (CAB15368) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
