GIT2 Rabbit Polyclonal Antibody (CAB15368)
- SKU:
- CAB15368
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | GIT2 Rabbit Polyclonal Antibody |
SKU: | CAB15368 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-510 of human GIT2 (NP_476511.1). |
Sequence: | ASRL EKQN STPE SDYD NTPN DMEP DGMG SSRK GRQR SMVW PGDG LVPD TAEP HVAP SPTL P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | PKL; CAT2; CAT-2; GIT2 |
Positive Sample: | A-431,LO2,Jurkat,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | nucleoplasm, presynapse, synapse |
Calculated MW: | 85kDa |
Observed MW: | 84kDa |
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Purification Method: | Affinity purification |
Gene ID: | 9815 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |