The GIP Polyclonal Antibody (CAB6230) is a valuable tool for researchers studying Gastric Inhibitory Polypeptide (GIP), a hormone that plays a key role in regulating insulin secretion and glucose metabolism. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the GIP protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it well-suited for investigations in the fields of endocrinology and metabolic disorders.
GIP, also known as glucose-dependent insulinotropic polypeptide, is an important regulator of glucose homeostasis and energy metabolism. Dysregulation of GIP signaling has been implicated in the development of conditions such as type 2 diabetes and obesity, making it an attractive target for therapeutic interventions. By studying the function of GIP and its associated pathways, researchers can gain insights into potential treatment strategies for metabolic diseases and related complications.
Product Name:
GIP Rabbit Polyclonal Antibody
SKU:
CAB6230
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-153 of human GIP (NP_004114.1).
This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion.
Purification Method:
Affinity purification
Gene ID:
2695
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse small intestine, using GIP Rabbit pAb (CAB6230) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
