GINS1 Antibody (PACO19241)
- SKU:
- PACO19241
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GINS1 Antibody (PACO19241)
The GINS1 Polyclonal Antibody (PAC019241) is a valuable tool for researchers studying the GINS1 protein, an essential component of the GINS complex involved in DNA replication. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the GINS1 protein, researchers can effectively detect and analyze its expression in various cell types, making it ideal for studies in genetics, cell biology, and cancer research.
GINS1 plays a crucial role in DNA replication and cell proliferation, making it a key target for research into diseases such as cancer where dysregulation of these processes occurs. Understanding the function and regulation of GINS1 is essential for developing therapies aimed at targeting abnormal cell growth and division. The GINS1 Polyclonal Antibody provides researchers with a reliable tool to further explore the role of GINS1 in health and disease.
| Antibody Name: | GINS1 Antibody (PACO19241) |
| Antibody SKU: | PACO19241 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human GINS1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19241(GINS1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19241(GINS1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | DNA replication complex GINS protein PSF1 is a protein that in humans is encoded by the GINS1 gene. The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function. Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. |
| Synonyms: | GINS complex subunit 1 (Psf1 homolog) |
| UniProt Protein Function: | GINS1: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function. Belongs to the GINS1/PSF1 family.Protein type: Motility/polarity/chemotaxis; DNA replicationChromosomal Location of Human Ortholog: 20p11.21Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: 3'-5' DNA helicase activityBiological Process: DNA strand elongation during DNA replication |
| UniProt Protein Details: | |
| NCBI Summary: | The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q14691 |
| NCBI GenInfo Identifier: | 6226339 |
| NCBI Gene ID: | 9837 |
| NCBI Accession: | Q14691.1 |
| UniProt Secondary Accession: | Q14691,Q9NQE2, Q9NQI7 |
| UniProt Related Accession: | Q14691 |
| Molecular Weight: | 22,988 Da |
| NCBI Full Name: | DNA replication complex GINS protein PSF1 |
| NCBI Synonym Full Names: | GINS complex subunit 1 |
| NCBI Official Symbol: | GINS1Â Â |
| NCBI Official Synonym Symbols: | PSF1Â Â |
| NCBI Protein Information: | DNA replication complex GINS protein PSF1 |
| UniProt Protein Name: | DNA replication complex GINS protein PSF1 |
| UniProt Synonym Protein Names: | GINS complex subunit 1 |
| Protein Family: | Probable DNA replication complex GINS protein |
| UniProt Gene Name: | GINS1Â Â |
| UniProt Entry Name: | PSF1_HUMAN |
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