The GIMAP4 Polyclonal Antibody (PACO62627) is a valuable tool for researchers studying the GTPase of the immunity-associated protein 4 (GIMAP4) in immune regulation and cell signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot and immunohistochemistry applications.GIMAP4 is a key player in immune cell development and function, with implications in autoimmune diseases, infections, and cancer.
By targeting GIMAP4, researchers can gain a deeper understanding of the immune response mechanisms and potential therapeutic targets for immune-related disorders.With its specificity and reliability, the GIMAP4 Polyclonal Antibody is an essential tool for investigators in immunology, oncology, and other related fields looking to unravel the complexities of immune system regulation and dysfunction.
Antibody Name:
GIMAP4 Antibody (PACO62627)
Antibody SKU:
PACO62627
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human GTPase IMAP family member 4 protein (5-101AA)
Immunofluorescence staining of HepG2 cells with PACO62627 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.
Synonyms:
GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4), GIMAP4, IAN1 IMAP4
UniProt Protein Function:
GIMAP4: May play a role in regulating lymphocyte apoptosis. Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. Belongs to the IAN GTP-binding protein family.Protein type: HydrolaseChromosomal Location of Human Ortholog: 7q36.1Cellular Component: cytosolMolecular Function: GTP binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
