The GIMAP4 Polyclonal Antibody (PACO22358) is a valuable tool for researchers studying GIMAP4, a key protein involved in immune cell development and function. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GIMAP4 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.GIMAP4, a member of the GTPase family, plays a critical role in regulating the survival and proliferation of immune cells, including T cells and B cells.
Its involvement in immune system function makes it an important target for study in diseases such as cancer, autoimmune disorders, and immune deficiencies. Understanding the mechanisms by which GIMAP4 influences immune cell activity is essential for the development of novel therapeutic strategies aimed at modulating immune responses in various pathological conditions.
Antibody Name:
GIMAP4 Antibody (PACO22358)
Antibody SKU:
PACO22358
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human GIMAP4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HeLa cells, HT-29 cells and RAW264.7 cells, using GIMAP4 antibody.
Background:
May play a role in regulating lymphocyte apoptosis By similarity. Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.
Synonyms:
GIMA4; GTPase; IMAP 4; IAN1; IMAP family member 4
UniProt Protein Function:
GIMAP4: May play a role in regulating lymphocyte apoptosis. Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. Belongs to the IAN GTP-binding protein family.Protein type: HydrolaseChromosomal Location of Human Ortholog: 7q36.1Cellular Component: cytosolMolecular Function: GTP binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
