The Gimap4 Polyclonal Antibody (PACO09466) is a valuable tool for research involving Gimap4, a protein that plays a key role in immune cell function and regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot analysis. By binding specifically to the Gimap4 protein, researchers can effectively detect and study its expression in different cell types, making it an essential component for studies in immunology and autoimmune diseases.Gimap4 is a critical regulator of immune cell survival and function, particularly in T cells. Dysregulation of Gimap4 has been implicated in autoimmune disorders, inflammatory diseases, and immune deficiencies, highlighting its importance in understanding immune system homeostasis.
Investigating the role of Gimap4 using this antibody can provide valuable insights into the mechanisms underlying immune-mediated pathologies and aid in the development of targeted therapies for these conditions.Overall, the Gimap4 Polyclonal Antibody (PACO09466) is a reliable reagent for researchers interested in exploring the functions of Gimap4 in immune responses and disease pathogenesis. Its specificity and sensitivity make it an essential tool for advancing our understanding of immune regulation and potentially identifying novel therapeutic targets for immune-related disorders.
GTPase, IMAP family member 4;GIMAP4;FLJ11110;HIMAP4;IAN1;IMAP4;MSTP062;hIAN1 ;
UniProt Protein Function:
GIMAP4: May play a role in regulating lymphocyte apoptosis. Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. Belongs to the IAN GTP-binding protein family.Protein type: HydrolaseChromosomal Location of Human Ortholog: 7q36.1Cellular Component: cytosolMolecular Function: GTP binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
