GHR Rabbit Polyclonal Antibody (CAB14735)
- SKU:
- CAB14735
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GHR Rabbit Polyclonal Antibody |
SKU: | CAB14735 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-260 of human GHR (NP_001229328.1). |
Sequence: | FSGS EATA AILS RAPW SLQS VNPG LKTN SSKE PKFT KCRS PERE TFSC HWTD EVHH GTKN LGPI QLFY TRRN TQEW TQEW KECP DYVS AGEN SCYF NSSF TSIW IPYC IKLT SNGG TVDE KCFS VDEI VQPD PPIA LNWT LLNV SLTG IHAD IQVR WEAP RNAD IQKG WMVL EYEL QYKE VNET KWKM MDPI LTTS VPVY SLKV DKEY EVRV RSKQ RNSG NYGE FSEV LYVT LPQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GHBP; GHIP; GHR |
Positive Sample: | LO2,Mouse heart,Mouse kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein, Single-pass type I membrane protein. |
Calculated MW: | 72kDa |
Observed MW: | 72kDa |
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2690 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |