The GH2 Monoclonal Antibody (PACO16411) is a valuable tool for researchers studying GH2, a protein that plays a crucial role in regulating cell growth and metabolism. This antibody, generated in mice, demonstrates high specificity and sensitivity for GH2 in various experimental settings, including immunofluorescence and flow cytometry.GH2, also known as growth hormone 2, is a key player in the endocrine system, promoting growth and development in both humans and animals. Dysregulation of GH2 signaling has been linked to a variety of disorders, including growth hormone deficiency and acromegaly.
Research into GH2 function is essential for developing novel therapies targeting growth-related conditions and metabolic diseases.With its reliable performance and broad applicability, the GH2 Monoclonal Antibody is an essential tool for researchers investigating the role of GH2 in physiology and disease. Whether studying normal growth processes or exploring the potential therapeutic implications of GH2 modulation, this antibody offers precise and reproducible detection of GH2 protein in a variety of biological samples.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16411(GH2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: PACO16411(GH2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16411(GH2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization.
Synonyms:
growth hormone 2
UniProt Protein Function:
GH2: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17q24.2
Cellular Component: extracellular region
NCBI Summary:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]
