The GGPS1 Polyclonal Antibody (CAB16233) is a valuable tool for researchers studying the GGPS1 protein, an enzyme involved in the biosynthesis of geranylgeranyl pyrophosphate (GGPP), a key intermediate in the mevalonate pathway. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GGPS1 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it well-suited for investigations in the fields of biochemistry and cancer research.
GGPS1 is a vital enzyme in the mevalonate pathway, which plays a crucial role in the production of essential molecules like cholesterol, steroid hormones, and isoprenoids. Dysregulation of this pathway has been linked to various diseases, including cancer, cardiovascular disorders, and metabolic syndromes. Studying the function of GGPS1 with the help of this antibody can provide insights into the underlying mechanisms of these conditions, potentially leading to the development of novel therapeutic strategies targeting the mevalonate pathway.
Product Name:
GGPS1 Rabbit Polyclonal Antibody
SKU:
CAB16233
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 164-300 of human GGPS1 (NP_001032354.1).
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9453
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of 293T cells, using GGPS1 antibody (CAB16233) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
