GGCX Rabbit Polyclonal Antibody (CAB1806)
- SKU:
- CAB1806
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | GGCX Rabbit Polyclonal Antibody |
SKU: | CAB1806 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 479-758 of human GGCX (NP_000812.2). |
Sequence: | QRIF DPRV DIVQ AAWS PFQR TSWV QPLL MDLS PWRA KLQE IKSS LDNH TEVV FIAD FPGL HLEN FVSE DLGN TSIQ LLQG EVTV ELVA EQKN QTLR EGEK MQLP AGEY HKVY TTSP SPSC YMYV YVNT TELA LEQD LAYL QELK EKVE NGSE TGPL PPEL QPLL EGEV KGGP EPTP LVQT FLRR QQRL QEIE RRRN TPFH ERFF RFLL RKLY VFRR SFLM TCIS LRNL ILGR PSLE QLAQ EVTY ANLR PFEA VGEL NPSN TDSS HSNP PESN PDPV HSEF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | VKCFD1; GGCX |
Positive Sample: | LO2,MCF7,HeLa,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein. |
Calculated MW: | 88kDa |
Observed MW: | 110kDa |
This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 2677 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |