The GGCX Polyclonal Antibody (CAB1806) is a high-quality antibody developed for research involving the GGCX protein, a crucial enzyme in the process of vitamin K-dependent gamma-carboxylation. This antibody, generated in rabbits, is specifically designed for use in Western blot applications and demonstrates high reactivity with human samples.GGCX is responsible for the activation of vitamin K-dependent proteins by converting specific glutamic acid residues to gamma-carboxyglutamic acid, playing a critical role in blood clotting and bone metabolism. Research on GGCX has shown its relevance in various diseases, including coagulopathy, osteoporosis, and cardiovascular disorders.
The GGCX Polyclonal Antibody enables the detection and analysis of this important enzyme in different cell types, making it an essential tool for studies in biochemistry, hematology, and medical research.Understanding the function and regulation of GGCX is key to developing targeted therapies for disorders related to vitamin K metabolism and blood clotting. By utilizing the GGCX Polyclonal Antibody in research, scientists can further explore the role of this enzyme in health and disease, potentially leading to the development of novel treatments for GGCX-related conditions.
Product Name:
GGCX Rabbit Polyclonal Antibody
SKU:
CAB1806
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 479-758 of human GGCX (NP_000812.2).
This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2677
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GGCX antibody (CAB1806) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
