The GGCT Polyclonal Antibody (CAB4957) is a valuable tool for researchers studying the GGCT protein, which plays a key role in glutathione metabolism and redox homeostasis. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to GGCT, this antibody allows for the accurate detection and analysis of GGCT protein levels in a variety of cell types.GGCT is a critical enzyme involved in the maintenance of cellular redox balance and protection against oxidative stress. Dysregulation of GGCT expression has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
Understanding the function and regulation of GGCT is essential for exploring potential therapeutic targets and developing strategies for managing oxidative stress-related conditions.The GGCT Polyclonal Antibody is a valuable tool for researchers investigating the role of GGCT in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it an essential component for studies in the fields of biochemistry, molecular biology, and translational medicine. By using this antibody, researchers can gain valuable insights into the functions of GGCT and its potential as a therapeutic target for a range of diseases.
Product Name:
GGCT Rabbit Polyclonal Antibody
SKU:
CAB4957
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human GGCT (NP_076956.1).
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
79017
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GGCT Rabbit pAb (CAB4957) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
