The GGA1 Polyclonal Antibody (CAB17126) is a valuable tool for researchers studying the GGA1 protein, which is involved in intracellular protein trafficking and sorting. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.GGA1 plays a crucial role in the transport of proteins between the Golgi apparatus and endosomes, making it essential for maintaining cellular homeostasis. Dysregulation of GGA1 has been implicated in various diseases, including neurodegenerative disorders and metabolic conditions.
By targeting the GGA1 protein, this polyclonal antibody enables researchers to study the function and localization of GGA1 in different cell types and tissues. Its utility in immunofluorescence and immunohistochemistry applications makes it an invaluable tool for investigations in cell biology and disease pathology. Gain insights into the complex mechanisms of protein trafficking with the GGA1 Polyclonal Antibody (CAB17126).
Product Name:
GGA1 Polyclonal Antibody
SKU:
CAB17126
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GGA1 (NP_001001560.1).
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
26088
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using GGA1 Rabbit pAb (CAB17126) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
