The GFRAL Polyclonal Antibody (PACO36906) is a specialized tool for researchers studying the GFRAL protein, which plays a key role in regulating energy homeostasis and body weight. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in applications such as Western blotting.GFRAL, also known as glial cell-derived neurotrophic factor receptor alpha-like, is a receptor for the hormone GDF15 and is primarily expressed in the brainstem. It is involved in regulating food intake, energy expenditure, and body weight, making it a promising target for research on metabolic disorders and obesity.
By targeting the GFRAL protein, researchers can gain insights into the mechanisms behind energy balance and potentially discover new therapeutic strategies for conditions related to metabolism and weight regulation. The GFRAL Polyclonal Antibody is a valuable tool for investigating the function of GFRAL in both normal physiology and disease states.
Western Blot. Positive WB detected in: Hela whole cell lysate, Mouse stomach tissue. All lanes: GFRAL antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO36906 at dilution of 1:100.
Background:
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Synonyms:
GDNF family receptor alpha-like, GFRAL, C6orf144
UniProt Protein Function:
GFRAL: Belongs to the GDNFR family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6p12.1Cellular Component: integral to membrane; intracellular; plasma membraneBiological Process: negative regulation of neuron apoptosis; stress-activated protein kinase signaling pathway
