The GFRAL Antibody (Biotin Conjugated) is a powerful tool for researchers studying GFRAL, a receptor implicated in energy balance and regulation of body weight. This antibody, produced through biotinylation for enhanced detection capabilities, specifically targets GFRAL in various cell types and tissues. It is ideal for use in techniques such as immunohistochemistry and flow cytometry, providing valuable insights into the function and localization of GFRAL in metabolic and obesity-related research.GFRAL, known as glial cell line-derived neurotrophic factor family receptor alpha-like, is a key player in the regulation of appetite and energy expenditure.
Understanding its role in metabolic processes and its potential as a therapeutic target for obesity and related conditions is crucial for the development of novel treatments. The GFRAL Antibody (Biotin Conjugated) offers researchers a reliable tool for investigating the mechanisms underlying GFRAL signaling and its implications for metabolic disorders.
Antibody Name:
GFRAL Antibody, Biotin conjugated (PACO36909)
Antibody SKU:
PACO36909
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human GDNF family receptor alpha-like protein (19-351AA)
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Synonyms:
GDNF family receptor alpha-like, GFRAL, C6orf144
UniProt Protein Function:
GFRAL: Belongs to the GDNFR family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 6p12.1Cellular Component: integral to membrane; intracellular; plasma membraneBiological Process: negative regulation of neuron apoptosis; stress-activated protein kinase signaling pathway
