The GFRA4 Polyclonal Antibody (PACO18432) is an essential tool for researchers studying GFRA4, a protein involved in neural development and function. This antibody, raised in rabbits, exhibits high specificity and sensitivity to GFRA4 in human samples, making it ideal for Western blot applications. By binding to GFRA4, this antibody allows for the detection and analysis of this critical protein in various cell types.GFRA4, a member of the GDNF receptor family, plays a crucial role in mediating the effects of growth factors on neuronal survival and differentiation. Its involvement in neural signaling pathways makes it a key player in the development and maintenance of the nervous system.
Research on GFRA4 is particularly relevant in the fields of neuroscience and neurobiology, as understanding its function can provide insights into neurological disorders and brain development.Overall, the GFRA4 Polyclonal Antibody (PACO18432) is a valuable tool for researchers looking to delve into the intricacies of neural biology and investigate the role of GFRA4 in various physiological and pathological conditions. Its high quality and reliability make it a crucial asset in the study of neural development and function.
Antibody Name:
GFRA4 Antibody (PACO18432)
Antibody SKU:
PACO18432
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human GFRA4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18432(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18432(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms:
GDNF family receptor α 4
UniProt Protein Function:
GFRA4: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Belongs to the GDNFR family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, GPI anchorChromosomal Location of Human Ortholog: 20p13-p12Cellular Component: plasma membraneMolecular Function: Ras guanyl-nucleotide exchange factor activityBiological Process: MAPKKK cascade
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
