Anti-GFRA4 Antibody (PACO18432)

Antibody Name:	GFRA4 Antibody (PACO18432)
Antibody SKU:	PACO18432
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human GFRA4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18432(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18432(GFRA4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:	The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms:	GDNF family receptor α 4

UniProt Protein Function:	GFRA4: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Belongs to the GDNFR family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, GPI anchorChromosomal Location of Human Ortholog: 20p13-p12Cellular Component: plasma membraneMolecular Function: Ras guanyl-nucleotide exchange factor activityBiological Process: MAPKKK cascade
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9GZZ7
NCBI GenInfo Identifier:	30173123
NCBI Gene ID:	64096
NCBI Accession:	Q9GZZ7.2
UniProt Secondary Accession:	Q9GZZ7,Q5JT74, Q9H191, Q9H192
UniProt Related Accession:	Q9GZZ7
Molecular Weight:	19,216 Da
NCBI Full Name:	GDNF family receptor alpha-4
NCBI Synonym Full Names:	GDNF family receptor alpha 4
NCBI Official Symbol:	GFRA4
NCBI Official Synonym Symbols:
NCBI Protein Information:	GDNF family receptor alpha-4
UniProt Protein Name:	GDNF family receptor alpha-4
UniProt Synonym Protein Names:	Persephin receptor
Protein Family:	GDNF family receptor
UniProt Gene Name:	GFRA4
UniProt Entry Name:	GFRA4_HUMAN

Antibodies

GFRA4 Antibody (PACO05013)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)