The GFRA4 Polyclonal Antibody (PACO05013) is a valuable tool for researchers studying the GFRA4 protein, a member of the GDNF receptor family involved in neuronal development and maintenance. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it an ideal choice for Western blot applications.GFRA4 plays a crucial role in the development and function of the nervous system, particularly in promoting the survival and differentiation of neurons. Dysregulation of GFRA4 has been implicated in various neurological disorders, making it a promising target for therapeutic interventions.
By using the GFRA4 Polyclonal Antibody, researchers can uncover the molecular mechanisms underlying GFRA4 signaling pathways and its potential impact on neural function.With its ability to detect GFRA4 protein in various cell types, this antibody is a valuable tool for studies in neuroscience, neurodevelopmental disorders, and neurodegenerative diseases. By gaining a deeper understanding of GFRA4 expression and function, researchers can contribute to the development of novel treatments for neurological conditions.
Antibody Name:
GFRA4 Antibody (PACO05013)
Antibody SKU:
PACO05013
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human GFR α -4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
GFRA4: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Belongs to the GDNFR family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, GPI anchorChromosomal Location of Human Ortholog: 20p13-p12Cellular Component: plasma membraneMolecular Function: Ras guanyl-nucleotide exchange factor activityBiological Process: MAPKKK cascade
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
