The GFRA2 Polyclonal Antibody (CAB2954) is a high-quality antibody designed for research involving the GFRA2 protein, which plays a key role in nerve growth factor signaling and neuronal development. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in various research applications.GFRA2 is a receptor for the GDNF family ligands and is involved in the development and maintenance of the nervous system. It is known to be crucial for the survival and differentiation of certain neuronal populations. The GFRA2 Polyclonal Antibody enables the detection and analysis of GFRA2 protein in different cell types, allowing researchers to further understand its function in neural development and neurological disorders.
The GFRA2 Polyclonal Antibody is validated for use in Western blot applications, providing reliable results for researchers studying the role of GFRA2 in neurobiology and related fields. By targeting the GFRA2 protein, this antibody is a valuable tool for investigating potential therapeutic strategies for neurodegenerative diseases and other neurological conditions.
Product Name:
GFRA2 Rabbit Polyclonal Antibody
SKU:
CAB2954
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 360-464 of human GFRA2 (NP_001486.4).
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2675
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GFRA2 antibody (CAB2954) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
